fluorouracil

Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.

以5-氟尿嘧啶为原经硅醚化、和四乙酰核糖缩合、皂化、酮缩醇形成、碘化、氢解及水解合成了去氧氟尿苷。本法工艺简便、条件缓和、原易得、成本低,总收率达54.6

Purpose: Options for single-agent fluoropyrimidine adjuvant therapy after bowel cancer resection include intravenous fluorouracil with leucovorin (FU/LV) or oral capecitabine.

目：肠道肿瘤切除术后氟脲嘧啶类单药辅助化疗可选四氢叶酸联合氟尿嘧啶持续静灌注（FU/LV）或者口服卡培它滨。