Over time, this lack of stimulation can cause zona fasciculata to physically shrink or become atrophic.

时间一长，过少刺激会导致束或萎。

This causes a decrease in CRH and ACTH, which in turn, shuts down cortisol production from the zona fasciculata.

这会降低CRH和ACTH，反过来阻止束制造皮质醇。

These ions trigger the final acrosomal reaction that releases the enzymes the sperm needs to work through the zona pellucida.

这些离子触发最终顶体反应，释放精子通过透明工作所需酶。

The excess ACTH overstimulates zona fasciculata of both adrenal glands, which grow larger and secrete excess cortisol.

过ACTH会过度刺激两个肾上腺束，使其增大并分泌过皮质醇。

Once it's past that, it runs into the zona pellucida, a layer of glycoprotein that covers the oocyte's plasma membrane.

一旦过了这个阶段，它就进入透明，覆盖卵母细胞质膜一层糖蛋白。

The zona thwarts the entry and fusion of more than one sperm, the smallest cell in the body.

透明阻止个精子（体内最细胞） 进入和融合。

In both adrenal adenomas and carcinomas, the cells of the zona fasciculata within the adrenal cortex start dividing abnormally and secrete excess cortisol.

在肾上腺腺瘤和肾上腺癌中，肾上腺皮质里束细胞开始异常分裂并分泌过皮质醇。

With less ACTH floating around, the zona fasciculata gets less stimulation to make cortisol, and eventually, cortisol levels go back down to the normal range again.

随着ACTH减少，束受刺激产生皮质醇减少，最后，皮质醇水平降低到正常范围内。

Second, cortisol starts cross-reacting with mineralocorticoid receptors, which normally only binds a related steroid hormone - mineralocorticoids which are secreted from the zona glomerulosa layer of the adrenal cortex.

第二，皮质醇对盐皮质激素受体产生交叉反应；此类受体一般只与一种相关类固醇激素结合，即从肾上腺皮质球层分泌盐皮质激素。

But only 100 or so will ultimately make it to the proximity of the egg, and only one will successfully penetrate through the armor of the zona pellucida.

但只有大约 100 个最终会到达卵附近，并且只有一个会成功穿透透明盔甲。

The most common primary cause is called idiopathic hyperaldosteronism, because the zona glomerulosa has an increase in the number of cells secreting aldosterone, but it's not really clear why this happens.

最常见原发性病因称为特发性醛固酮增症：这是由于球分泌醛固酮细胞数量增加，但目前尚不清楚为什么会发生这种情况。

The adrenal cortex is the outer part of the adrenal gland and is subdivided into three layers- the zona glomerulosa, the zona fasciculata, and the zona reticularis.

肾上腺皮质是肾上腺外层部分，皮质又分为三层：球、束和网。

In primary hyperaldosteronism, the main problem is that zona glomerulosa cells secrete high levels of aldosterone, and that aldosterone has a negative feedback effect on renin, and so it actually inhibits renin production.

在原发性醛固酮增症中，主要问题是球细胞分泌高水平醛固酮；醛固酮对肾素有负反馈作用，因而实际上抑制肾素生成。

All right, as a quick recap, hyperaldosteronism is the chronic, excess secretion of aldosterone from the zona glomerulosa of the adrenal gland, and these high aldosterone levels can lead to hypokalemia, hypernatremia, hypertension, and a metabolic alkalosis.

得！简单回顾一下：醛固酮增症是指肾上腺球长期分泌过醛固酮；这些高醛固酮水平可导致低钾血症、高钠血症、高血压与代谢性碱中毒。