Bulgarian psychiatrist Nikola Schipkowensky said that tricyclic antidepressants were inducing the disease to " change to a more chronic course."

保加利亚精神病医师 Nikola Schipkowensky 说，抗抑郁药物会使抑郁症状沿着“更加长期化的过程”演化。

The tricyclics are still used these days to some extent.

如今，化合物在某种程度上仍在使用。

Two of the older classes are called the monoamine oxidase inhibitors and the tricyclic antidepressants.

中两个较早的别称为单胺氧化酶抑制剂和抗抑郁药。

Unfortunately, tricyclics also interfere with a lot of other signalling mechanisms, which meant people could easily kill themselves by overdosing.

不幸的是，化合物还会干扰许信号机制，这意味着人们很容易因服药过量而自杀。

Tricyclics, an early generation of them, blocked protein channels called serotonin transporters through which serotonin is reabsorbed by a neuron after it has done its job.

化合物，它们的早期一代，阻断了称为血清素转运蛋白的蛋白质通道，血清素通过该通道在完成工作后被神经元重新吸收。

They're relatively effective. About 60% of people respond well to the tricyclics, but they have a lot of side effects, and they can be fatal in overdose.

它们相对有效。约 60% 的人对药物反应良好，但它们有很副作用，过量服用可能会致命。