Hepatic stellate cells (HSteC) are intralobular connective tissue cells presenting myofibroblast-like or lipocyte phenotypes.
肝脏星细胞
内结缔组织细胞,呈现肌
纤维细胞样或脂肪细胞
。
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When activated, the stellate cells lose vitamin A, proliferate, and start secreting secreting transforming growth factor beta1, or TGF-beta, which then causes them to produce collagen, which is the main ingredient in extracellular matrix, fibrosis, and scar tissue.
激后的星形细胞失去维生素A,
且开始大量增生,分
转化生长
ß,即TGF-ß,随之导致其生成胶原;胶原是细胞外基质、纤维化和疤痕组织的重要成分。