Infection of tumor cells with conditionally replicating adenovirus results in tumor-specific replication,subsequent oncolysis and release of the virus progeny.
A recombinant HGP44 inhibited HIV-1 replication at a 50% effective concentration of approximately 2.5 micromolar, the researchers note, somewhat less potently than did P. gingivalis extracts.
The influence of the drug on the cytopathy of the myocardial cells,its effects on virus replication and the content of troponin in the supernatants of the cultured cells were kept under observation.