Still in his mid-50s, he suffered severe osteoarthritis.

50多岁的时候， 他就备受骨关节炎的折磨。

Even the most common type, osteoarthritis, is trickier to prevent than one might think.

即使要避见的骨关节炎，也比人们想象的难得多。

Which can boost the risk of osteoarthritis and the need for hip replacement in middle age.

这会增加骨关节炎的发病率从而使得患病者在中年时需要进行髋关节置换手术。

Nowadays, it's thought that inflammation does indeed play an important role in the development of osteoarthritis.

现如今，炎症反应被认为确实在骨关节炎病程发展中，起到了不可忽视的作用。

The origins of osteoarthritis can often be traced to a patient's early life, from any seemingly ordinary joint injury.

骨关节炎的病根，通可追溯到患者早些年看似普通的关节损伤。

Osteoarthritis is really common, and nearly everyone knows someone that suffers from it.

骨关节炎十分见，几乎每个人身边都有该病患者。

Dolly who had to be put down in 2003 had aged prematurely because she developed osteoarthritis at a relatively young age.

多利在相对年轻的岁数患上骨关节炎，因此未老先衰，2003年不得不被实施安乐死。

People can also develop things called osteoarthritis, where you actually lose cartilage and you have more kind of bone on bone.

人们也可以患上叫做骨关节炎的病，你实际上失去了软骨，你的骨头上有更多种类的骨头。

Finally, management and treatment of osteoarthritis can involve non-pharmacological approaches, like losing weight or moderate exercise, as well as physical therapy.

后，骨关节炎的治疗和处理使用非药物疗法，如减肥或适当运动，以及物理疗法。

The researchers looked for signs of diabetes, high blood pressure, and osteoarthritis.

研究人员寻找糖尿病、高血压和骨关节炎的迹象。

And they actually randomized these women who had knee osteoarthritis into one of two groups.

戴维斯：他们实际上将这些患有膝骨关节炎的女性随机分成了两组。

We have, for example, an epidemic of osteoarthritis today.

例如，我们现在有一种骨关节炎的流行病。

And his knees have the early signs of osteoarthritis.

他的膝盖出现了早期骨关节炎的迹象。

This leads to the flood of enzymes and degradation seen in osteoarthritis, but is driven by different inflammatory proteins called cytokines.

也出现骨关节炎中产生大量酶和削弱关节的现象，但由不同的炎症蛋白引起，这种蛋白称为细胞因子。

And I think, you know, we often used to think about osteoarthritis as a wear and tear problem.

而且我认为，我们过去把骨关节炎看作是磨损导致的问题。

The origins of osteoarthritis can often be traced to a patient’s early life, from any seemingly ordinary joint injury.

骨关节炎的起源通可以追溯到患者的早年生活，源于任何看似普通的关节损伤。

If Dolly was a typical example, it was possible that clones would die early of age-related diseases, like osteoarthritis.

如果多莉是一个典型的例子，克隆人有可能会早死于与年龄有关的疾病， 比如骨关节炎。

It's probably more effective than most traditional treatments for osteoarthritis.

它可能比大多数传统治疗骨关节炎的方法更有效。

According to a 2013 prediction by the World Health Organisation, 130 million people globally will have osteoarthritis by 2050.

根据世界卫生组织2013年的预测，到2050年，全球将有1.3亿人患有骨关节炎。

Higher rates of diabetes, hypertension, cardiovascular disease, even some cancers, osteoarthritis and a clear link to mental conditions such as depression.

更高的糖尿病、高血压、心血管疾病、甚至某些癌症、骨关节炎的发病率，以及与抑郁症等精神状况的明确关联。