The midgut gland cell differentiation occurs at Z2, There are 4 types of cells, i. e., embryonic cell (E-cell), fibrillar cell (F-cell), blister cell (B-cell) and resorptive cell(R-cell).
The results of biochemical analysis indicated that the difference of the activity of carboxylesterase and esterase isozymes in the larval midguts were the main mechanism of this selective toxicity.