The growth,infiltration and metastasis of oncoma depend on tumor angiogenesis.Vascular endothelial growth factor(VEGF)is the most important irritant factor of angiogenesis.
There's very little dermal absorption, skin allergy reactions, irritants, reactions, so the less regulation there in Europe has given them more options.
This may be due to reasons ranging from exposure to additional pollutants and environmental irritants to difficulties in obtaining medical care or treatment.