As beta cells are lost and insulin levels decrease, glucose levels in the blood start to increase, and patients develop hyperglycemia, which leads to similar clinical signs that I mentioned before, like polyphagia, glycosuria, polyuria, and polydipsia.

丧失β细胞后，胰岛素水平开始下降，血糖水平开始上升，而患者出现高血糖，最终导致之前提及的临床表现，即食、糖、。

In this case, though, it's a slower process since there's also an osmotic diuresis or increased urination from the hyperglycemia, or high blood sugar.

在这种情况下，过程较为缓慢，因为也存在渗透性利，或因高血糖而引起的排增。

Other causes include metabolic disorders like nonketotic hyperglycemia; and mutations in the genes coding for normal development of the neurons.

其他原因包括代谢紊乱，如非酮类高血糖症以及编码控制神经元正常发育的基因发生突变。

When that fails to happen, it’s called insulin resistance or hyperglycemia.

如果这种情况没有发生， 则称为胰岛素抵抗或高血糖症。