Obesity and metabolic syndrome are recognized as strong risk factors for hand OA, but also knee OA, where low-grade chronic inflammation and systemic metabolic alterations disrupt joint tissue homoeostasis.

肥胖和代谢综合征被认为是手部骨关强风因素，是膝关骨关风因素，在这些情况下，低级别慢性症和全身代谢改变会扰乱关组织稳态。