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Osmosis-遗传

CAG codes for the amino acid glutamine, so people with Huntington disease patients will have 36 or more glutamines in a row in the huntingtin protein.

因为CAG序的是谷氨胺(氨基酸),所以在HD患者体,huntingtin蛋白质上会有36个以上连续的谷氨胺。

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Osmosis-神经

The specific way in which extra glutamines causes the disease's symptoms isn't fully understood but the abnormal protein seems to aggregate within the neurons of the cerebellum and the spinal cord, causing them to die.

过多谷氨胺导致疾病症状的具体机制尚未完全清楚,但异常蛋白质似乎聚集在小脑和脊髓的神经元导致神经元的死亡。

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Osmosis-神经

In some cases, the involved gene contains a triplet repeat where the nucleotides C, A and G are repeated multiple times in a row and since CAG codes for the amino acid glutamine, the encoded protein will have multiple extra glutamines in a row.

在某些情况下,涉及的基因包含一个三联体重复序,即核苷酸C、A和G连续重复多次;由于CAG编码谷氨胺,编码的蛋白质将具有连续多个额外的谷氨胺。

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