Abstract: CD105 is a kind of glycoproteins idio-expressed in the neogenetic vessel endothelium,which always marks the cells with proliferation activity.
During stasis, platelets and other clotting factors contact the endothelium, and prolonged interaction leads to clotting factor adhesion, and, ultimately, activation of the clotting cascade.
After that, some platelets adhere to the damaged vessel wall, and become activated by collagen and tissue factor, proteins which are normally kept separated from the blood by an intact endothelium.
Finally, there's the innermost layer of the heart called the endocardium, which is made of a relatively thin layer of endothelium which is the same layer of cells that line the blood vessels.
Normally, after a cut and damage to the endothelium, or inner lining of blood vessel walls, there's an immediate vasoconstriction or narrowing of the blood vessel which limits the amount of blood flow.
The cool thing about this layer is that it contains the endothelium, which you may remember is made up of simple squamous epithelium tissue and is continuous with the lining of the heart.
Normally, the process starts with damage to the endothelium, or inner lining of blood vessel walls, after which there's an immediate vasoconstriction or narrowing of the blood vessel which limits the amount of blood flow.
The moment the endothelium, that is the inner lining of the red blood vessel, when it feels injury, it sends a whole cascade of markers and signals and say, " Yo, I'm like, I'm cut here."