CONCLUSION The QSAR model can predict the MIC of carbapenems and select the biologic-activity compounds, which offer a new way of thinking and references of carbapenems compounds design.
结论所建立的QSAR模有效地进行碳青霉烯类化物的MIC值的预测和化物,这类新药开发提供新的参考和思路。
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It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.
肺炎克雷伯杆菌也是一种多重耐药菌,如果β-内酰胺酶,可用头孢菌、基糖苷、氟喹诺酮及碳青霉烯药治疗;如果ESBL,可只应用碳青霉烯进行治疗;如果碳青霉烯酶,则应用多粘菌、替加环或磷霉进行治疗。