As single laevo-enantiomers,ropivacaine and levobupivacaine which have been generally researched are attracting extensive attention for their better anaesthetic effect and less system toxicity.
The British Formula One Racing driver Jenson Button and his wife have been burgled while on holiday in France by thieves who apparently pumped anaesthetic gas into their villa.
And from loving it with a vanity that was almost masculine—it had been in the nature of a triumphant and dazzling career—she became suddenly anaesthetic to it. She retired.
Then I realised that Holmes is a cocaine addict and Freud had been an early proponent of cocaine, starting as a use for anaesthetic during eye surgery, but he also was a user.