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Randomized aldactone evaluation study (RALES) showed that adding aldosterone antagonist in the treatment of heart failure may decrease 30% mortality of all causes.

内酯评估研究表明在心力衰竭治中加用醛甾酮拮抗药可使总死亡30%。

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Osmosis-心血管

Another example is a tumor that produces excess aldosterone, which just like renin, leads to fluid retention.

另一个例子是肿瘤生长也会产生过醛固一种类似于物质,会导致液体积存。

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Osmosis-内分泌

With these medications around, aldosterone can't exert its effects.

有了这些药物,醛固就无法发挥其作用了。

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Osmosis-泌尿

An important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

脏中一种帮助调节钾重吸收或分泌重要激醛固

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WIL生活启示录

This suggests that people actually following the WHO guidelines are chronically raising their aldosterone.

也就是说,遵循世卫组织关于盐摄入量建议人们,他们体内醛固长期处于较高水平

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Osmosis-泌尿

Other pathological conditions that cause increased aldosterone levels include compensated heart failure and cirrhosis.

其他导致醛固水平病理状况包括代偿期心衰和肝硬化。

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WIL生活启示录

Aldosterone has it's purpose, but it's not a hormone you want to regularly have high levels of.

醛固有其作用,但在人体中,这种荷尔蒙水平不能太高。

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Osmosis-内分泌

The diagnosis of hyperaldosteronism is mainly done by measuring levels of renin and aldosterone.

醛固诊断主要通过测定醛固水平来完成

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Osmosis-内分泌

Aldosterone is part of a hormone family or axis which work together and are called the renin-angiotensin-aldosterone system.

醛固属于一特定激家族或激一部分,这些激共同作用,被称为-血管紧张-醛固系统。

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But, as I mentioned earlier, this renin angiotensin aldosterone system is stimulated by low salt intake.

但是,正如我之前提到,低盐饮食会导致 RAA 系统活跃。

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Osmosis-泌尿

Now, an important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

所以,脏中有一种重要可以帮助调节钾重吸收和分泌,这就是醛固

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Osmosis-内分泌

So in this case aldosterone levels are high and renin levels are low in.

因此,在这种情况下,醛固水平较高,水平较低。

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Osmosis-内分泌

Secondary causes of hyperaldosteronism are usually due to excess aldosterone production in response to high levels of renin.

醛固继发性原因通常是由于高水平导致醛固生成过

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As this study shows, a low salt diet increases aldosterone by more than 3 fold in healthy people.

这项研究显示,健康正常人采用低盐饮食,其体内醛固水平将加 3 倍有余。

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High aldosterone is associated with increased inflammation, Chronic kidney disease, Osteoporosis, and cardiovascular disease.

醛固水平会加体内炎症,导致慢性病、骨质疏松症以及心血管疾病。

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WIL生活启示录

These drugs inhibit Angiotensin Converting Enzyme, hindering an important step in the RAA system resulting in lower aldosterone and lower blood pressure.

这种药物通过抑制血管紧张转化酶作用(RAA 系统关键作用之一),以达到降低醛固水平及血压

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Osmosis-内分泌

Hyperaldosteronism can happen due to primary causes which is where the adrenal gland itself is responsible for the excess production of aldosterone.

醛固症可以是原发性,即上腺本身产生了过量醛固

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WIL生活启示录

On the flip side of aldosterone, there is a group of hormones called natriuretic hormones, i. e. sodium urinating hormones.

醛固另一面有一组激叫利钠激,也就是钠尿荷尔蒙。

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WIL生活启示录

Another study shows that when salt intake drops below 1.5 teaspoons per day, a significant increase in renin and aldosterone occurs.

另一项研究显示,当盐摄入量降至每天 1.5 茶匙以下,人体中醛固水平将大幅上升。

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Osmosis-泌尿

Aldosterone increases sodium channels on the lumen side of the principal cell and sodium-potassium pumps on the basolateral side of the principal cells.

加主细胞腔面钠离子、钾离子通道和基底面钠-钾泵数量。

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Osmosis-内分泌

Less aldosterone floating around in the blood causes the body to start dumping sodium from the blood into the urine.

血中醛固减少使得尿钠排出

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