Frenchman Charles Gerhardt had treated acetylchloride with sodium salicylate in 1853, but Hoffmann's version, which was instigated by his supervisor, Arthur Eichengruen, was the first to be suitable for medical use.

法国人·格哈特在1853年曾将乙酰氯与水杨酸钠进行处理，霍夫曼的改良版本，由其导师阿瑟·艾兴格林推，是首个适合医疗用途的。