Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以克拉霉素为起始原料,经水解、乙、碳、氧、脱碳、、氨基甲和合等反应合成目标合物。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

组蛋白乙和去乙由一对功能相互拮抗的蛋白酶——组蛋白乙基转移酶和组蛋白去乙酶负责。