Objective To evaluate the performance of complement depend micro-lymphocytotoxicity assay (CDMA) for the detection of human leucocyte antigen-B27 (HLA-B27).
So, specifically with autoimmune hepatitis, there seems to be some sort of connection between these particular " self-proteins" , the HLA-DR, and mounting an attack against your own liver.
Genetic risk factors include being a woman and having genes that encode a specific type of immune molecule called HLA-DR2 which is used to identify and bind to foreign molecules.
Also though, an important piece of the genetic puzzle is the Human Leucocyte Antigen system, shortened to HLA, which is this location of genes on chromosome 6 that regulate our immune functions.
The New York patient - who has a mixed-race ancestry - was given umbilical cord blood of an infant combined with adult stem cells, with both donors only a partial HLA match.
They would need to have a close enough human leukocyte antigen or HLA match to maximise the chances the transplant would work - as well as the rare genetic abnormality conferring HIV resistance.
他们需要有足够接近的人类白细胞抗原或 HLA 匹配,以最大限度地提高移植成功的机会——以及罕见的遗传异常导致 HIV 耐药。