One technique they've used utilizes AAV technology.

们的一项技术是 AAV 技术。

The AAV stands for adeno-associated virus.

AAV 代表腺相关病毒。

And we don't understand the disease well enough to go in and somehow rescue those dying dopamine cells with AAVs.

且我们对这种疾病的了解还不够充分，无法进入并以某种方式 AAV 拯救那些垂死的多巴胺细胞。

They went back to their mouse model where they were boosting IFNO therapeutically with the AAV.

们回到们的小鼠模型中，通过腺相关病毒（AAV）治疗性地增强IFNγ。

Depending on the study, they did this by either using AAV to inhibit their target gene or CRISPR to cut it out completely.

根据这项研究，们要么 AAV 抑制目标基因，要么 CRISPR 将其完全切除。

In papers published that year, two research groups did just that by using AAV or CRISPR to make a simple genetic edit in glia cells.

在当年发表的论文中，两个研究小组通过 AAV 或 CRISPR 在神经胶质细胞中进行简单的基因编辑做到这一点。

And not only that, but removing the CDC's also made the therapeutic IFO treatment, the AAV delivery we talked about, much less effective.

不仅如此，去除树突状细胞（DCs）后，我们之前讨论过的治疗性IFO疗法和AAV递送也变得低效得多。

But in this case, researchers can edit the genes carried by the AAV, and provide new instructions to tell the cell what to make or how to behave.

但在这种情况下，研究人员可以编辑 AAV 携带的基因，并提供新的指令告诉细胞制造什么或如何表现。