Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.
以5-氟尿嘧啶为原料经硅醚
、和四乙酰核糖缩
、
、酮缩醇形
、碘、氢
等反应了去氧氟尿苷。本法工艺简便、条件缓和、原料易得、本低,总收率达54.6
，部分未经过人工审核，其表达内容亦不代表本软件的观点；若发现问题，欢迎向我们指正。
